Testosterone Replacement Therapy (TRT) is a hormone replacement therapy which has evolved in recent years and within a short period of time, it has reached its highest level of prescriptions in the US. The Food and Drug Administration (FDA) had approved TRT to treat male hypogonadism which means low testosterone levels due to disorders of the testicles, pituitary gland, or brain. Testosterone is made available in forms like topical gel, transdermal patch, buccal system (applied to upper gum or inner cheek), and injection. TRT may also be prescribed to lessen the effects or delay the onset of normal male aging.
The manufacturers involved are AbbVie, Actavis, Inc. (formerly Watson Pharmaceuticals), Eli Lilly and Company, Teva Pharmaceuticals, Pharmacia & Upjohn Company, Endo Pharmaceuticals, Columbia Laboratories, Auxilium Pharmaceuticals.
Studies show that there is an evidence of an increased risk of heart attack or stroke associated with testosterone use especially for AndroGel, Testosterone Therapies.