Abilify (aripiprazole) is an atypical antipsychotic developed by Otsuka Pharmaceutical Co., Ltd. In 1999, Otsuka partnered with Bristol-Myers Squibb (BMS) to complete development, obtain approvals, and market aripiprazole in the U.S. In November 2002, it was approved by the FDA for the treatment of schizophrenia in adults. In October 2007, the FDA approved Abilify for the treatment of schizophrenia in adolescents aged 13-17 years. In 2004, it was approved to treat symptoms related to Bipolar I Disorder in adults. Later in 2008, it was approved to treat patients 10 to 17 years old. This was followed by an approval for the treatment of unipolar depression as an adjunct with an antidepressant medication in November 2007. In 2009, it was approved to treat irritability associated with an autistic disorder for patients 6 to 17 years old.
When there is an imbalance, Abilify either increases or decreases the levels of dopamine or serotonin in the brain. A large number of patients treated with Abilify were reported to develop the habit of compulsive gambling and got racked up with large amounts of debts. Other pathological behaviors like excessive eating, excessive shopping, and Hypersexuality are also noted who started using or increased dosage of Abilify.
Young patients with depression and elderly patients with dementia consuming Abilify are found to be at a high risk of suicidal thoughts or actions. It also increases the risk of developing diabetes.
In 2013, the marketing rights were returned to Otsuka by BMS; however, BMS kept manufacturing the drug.
In November 2017, the FDA approved Abilify MyCite, a digital pill containing a sensor intended to record when its consumer takes their medication.