Invokana (Canagliflozin) is a drug used for the treatment of type 2 diabetes. It was developed by Mitsubishi Tanabe Pharma and is marketed under license by Janssen, a division of Johnson & Johnson in the United States. The U.S. Food & Drug Administration (FDA) approved Invokana on March 29, 2013, for the treatment of type 2 diabetes. It belongs to the class sodium-glucose cotransporter 2 (SGLT2) inhibitor. Glucose is reabsorbed from urine by the action of SGLT2, which is an enzyme in the kidney tubule; by inhibiting the action of SGLT2, Invokana helps the kidneys get rid of glucose from the bloodstream.
According to the guidelines published by ADA (American Diabetes Association), Invokana may be considered to reduce major cardiovascular events after lifestyle management and metformin in patients with T2D and established cardiovascular disease.
Over a period of time, Invokana has been linked to aggravating certain medical conditions one of them being 'Ketoacidosis,' a condition in which the body produces high levels of blood acids known as ketones. If left untreated, this condition can be fatal. Since its launch in the U.S. markets, several patients have developed ketoacidosis to the point of needing an emergency room visit or hospitalization.
The most common side effects include genital yeast infections, urinary tract infections, and changes in urination. The side effects listed by the manufacturer is weight loss of between two to three percent. It is also known to lower blood pressure anywhere between three to five mmHg. However, the major side effects mentioned in various lawsuits, are not listed by the manufacturer.
Diabetes causes severe foot problems due to poor circulation, nerve damage, and peripheral arterial disease. In some cases, these problems require a partial or complete amputation of the foot or lower leg. Many lawsuits against Janssen involving Invokana accuse the company of failing to warn them of the higher risk of amputation caused due to the intake of the drug.The most common side effects include genital yeast infections, urinary tract infections, and changes in urination. A weight loss of two to three percent is listed as side effects by the manufacturer. It is also known to lower blood pressure anywhere between three to five mmHg. However, the major side effects mentioned in various lawsuits are not listed by the manufacturer.