• Eliquis (Apixaban) Medical Record Review & Outsourcing Services

Eliquis (Apixaban) is an oral antiplatelet belonging to the class of direct factor Xa inhibitors. It is manufactured by Bristol-Myers Squibb and Pfizer under the trade name Eliquis. It acts by inhibiting Factor Xa, which is a key blood clotting protein that decreases the level of a thrombin, thus Eliquis indirectly decreases clot formation. Eliquis was approved by the U.S Food and Drug Administration FDA on December 28, 2012, for the prevention of stroke in people with Atrial fibrillation.

Eliquis is used for

  • Reduction of Risk of Stroke and Systemic Embolism in Non-valvular Atrial Fibrillation
  • Prophylaxis of Deep Vein Thrombosis Following Hip or Knee Replacement Surgery
  • Treatment of Deep Vein Thrombosis
  • Treatment of Pulmonary Embolism
  • Reduction in the Risk of Recurrence of DVT and PE

In June 2014, a patient started on Eliquis died of gastrointestinal bleeding as a complication within two months. It was observed that Eliquis can increase the risk of uncontrollable bleeding, and is more prone when taken at the same time with Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs).

There has been no recall of Eliquis as of November 2017.

Eliquis does not have an antidote to stop the bleeding complications.

Serious Alleged Injuries may include:

  • Gastrointestinal (GI) bleeding
  • Rectal bleeding
  • Kidney bleeding
  • Cerebral hemorrhage
  • Hypovolemic shock
  • Death

FDA Safety Warnings:

2012 Black Box warning: discontinuing Eliquis in patients without adequate continuous anticoagulation increases the risk of stroke.

2014: Another boxed warning for Eliquis to include a warning for a spinal/epidural hematoma in patients treated with Eliquis who are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis.

Legal Updates:

The first lawsuit against Eliquis was filed in July 2015. The manufacturers claim that the Eliquis is superior in safety and effectiveness as compared to Warfarin, but there is a lack of clear evidence in its support.

In February 2017, the U.S. Judicial Panel on Multidistrict Litigation (JPML) consolidated pending Eliquis lawsuits into a multidistrict litigation (MDL No. 2754- IN RE: Eliquis (Apixaban) Products Liability Litigation under Judge Denise Cote) in the Southern District of New York. The MDL was assigned to Cote to litigate the pending actions in various locations.


  • Usage of Eliquis
  • Duration of Eliquis usage
  • Indication for Eliquis usage
  • Complications and treatment after Eliquis usage

Medical Record Review and claim validation of Eliquis case should take approximately 3 hours in most instances; however, this approximation may vary in cases based on the volume of records.



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