Zoloft (sertraline hydrochloride), an antidepressant, is a class of drugs called selective serotonin reuptake inhibitors (SSRIs). It was developed and manufactured by Pfizer in the early 90's. The Food and Drug Administration (FDA) approved Sertraline in 1999. This drug affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms. In 2013, it was the most prescribed antidepressant. It is administered both in adults and children to treat conditions such as depression, obsessive-compulsive disorder, post-traumatic stress disorder, and anxiety.